Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin - review of the literature

Working by a distinct cell wall-specific mechanism of action, the echinocandin class of antifungals has substantially expanded the range of available treatments for invasive Candida infections. Anidulafungin, caspofungin and micafungin were investigated versus drugs from earlier antifungal classes in large clinical trials that demonstrated their excellent clinical and microbiological efficacy in the primary treatment of invasive candidiasis. Therefore, and supported by a number of favourable pharmacological characteristics, the echinocandins rapidly became established in guidelines and clinical practice as primary treatment options for moderately to severely ill patients with invasive candidiasis. This article reviews the relevant clinical evidence that forms the basis for the use of echinocandins in the management of invasive candidiasis, and discusses their current role in the context of recent guideline recommendations and treatment optimization strategies

Utility based pricing and hedging of jump diffusion processes with a view to applications

We discuss utility based pricing and hedging of jump diffusion processes with emphasis on the practical applicability of the framework. We point out two difficulties that seem to limit this applicability, namely drift dependence and essential risk aversion independence. We suggest to solve these by a re-interpretation of the framework. This leads to the notion of an implied drift. We also present a heuristic derivation of the marginal indifference price and the marginal optimal hedge that might be useful in numerical computations.Comment: 23 pages, v2: publishe

The Nub of an Automorphism of a Totally Disconnected, Locally Compact Group

To any automorphism, $\alpha$, of a totally disconnected, locally compact group, $G$, there is associated a compact, $\alpha$-stable subgroup of $G$, here called the \emph{nub} of $\alpha$, on which the action of $\alpha$ is topologically transitive. Topologically transitive actions of automorphisms of compact groups have been studied extensively in topological dynamics and results obtained transfer, via the nub, to the study of automorphisms of general locally compact groups. A new proof that the contraction group of $\alpha$ is dense in the nub is given, but it is seen that the two-sided contraction group need not be dense. It is also shown that each pair $(G,\alpha)$, with $G$ compact and $\alpha$ topologically transitive, is an inverse limit of pairs that have `finite depth' and that analogues of the Schreier Refinement and Jordan-H\"older Theorems hold for pairs with finite depth

Understanding Marine Microbes, the Driving Engines of the Ocean

When you hear the word microbes, what comes to your mind? Something much too small to see and that makes you fall ill? Just because some microbes cause diseases that does not mean they are all evil. For example, in the marine (ocean) environment, the vast majority of microbes are good ones. They are the “driving engines” of the ocean and are essential for the health of our whole planet. Unfortunately, most of the marine microbes and their interactions with the marine environment are poorly understood. So, it is important to get an idea of which microbes are helping us and how they are doing this. These data will provide scientists with the knowledge to fight against big global challenges, such as climate change and environmental pollution. Unfortunately, it is very hard to study marine microbes due to their microscopic size, huge diversity, and their big home – the ocean. Therefore, we would like to engage “citizen scientists” in this project to help us to sample marine microbes so that we can identify them

Overview of (pro-)Lie group structures on Hopf algebra character groups

Character groups of Hopf algebras appear in a variety of mathematical and physical contexts. To name just a few, they arise in non-commutative geometry, renormalisation of quantum field theory, and numerical analysis. In the present article we review recent results on the structure of character groups of Hopf algebras as infinite-dimensional (pro-)Lie groups. It turns out that under mild assumptions on the Hopf algebra or the target algebra the character groups possess strong structural properties. Moreover, these properties are of interest in applications of these groups outside of Lie theory. We emphasise this point in the context of two main examples: The Butcher group from numerical analysis and character groups which arise from the Connes--Kreimer theory of renormalisation of quantum field theories.Comment: 31 pages, precursor and companion to arXiv:1704.01099, Workshop on "New Developments in Discrete Mechanics, Geometric Integration and Lie-Butcher Series", May 25-28, 2015, ICMAT, Madrid, Spai

Weak Poisson structures on infinite dimensional manifolds and hamiltonian actions

We introduce a notion of a weak Poisson structure on a manifold $M$ modeled on a locally convex space. This is done by specifying a Poisson bracket on a subalgebra \cA \subeq C^\infty(M) which has to satisfy a non-degeneracy condition (the differentials of elements of \cA separate tangent vectors) and we postulate the existence of smooth Hamiltonian vector fields. Motivated by applications to Hamiltonian actions, we focus on affine Poisson spaces which include in particular the linear and affine Poisson structures on duals of locally convex Lie algebras. As an interesting byproduct of our approach, we can associate to an invariant symmetric bilinear form $\kappa$ on a Lie algebra \g and a $\kappa$-skew-symmetric derivation $D$ a weak affine Poisson structure on \g itself. This leads naturally to a concept of a Hamiltonian $G$-action on a weak Poisson manifold with a \g-valued momentum map and hence to a generalization of quasi-hamiltonian group actions

The effect of consumer ratings and attentional allocation on product valuations

Online marketplaces allow consumers to leave reviews about the products they purchase, which are visible to potential customers and competitors. While the impact of reviews on valuations of worth and purchasing decisions has been intensively studied, little is known about how the reviews themselves are attended to, and the relation between attention and valuations. In three studies we use eye-tracking methodologies to investigate attention in subjective monetary valuations of consumer goods. We find that, when evaluating consumer goods, individuals’ attention to ratings are related to their frequencies, attention to positive or negative information is related to subjective valuations, and that perspective (owner vs. non-owner) influences the type of information attended to. These findings extend previous research regarding the valuations of risky prospects as implemented in abstract monetary gambles and suggest that similar cognitive processes might underlie both types of tasks

Ten steps toward a better personality science - How quality may be rewarded more in research evaluation

This target article is part of a theme bundle including open peer commentaries (https://doi.org/10.5964/ps.9227) and a rejoinder by the authors (https://doi.org/10.5964/ps.7961). We point out ten steps that we think will go a long way in improving personality science. The first five steps focus on fostering consensus regarding (1) research goals, (2) terminology, (3) measurement practices, (4) data handling, and (5) the current state of theory and evidence. The other five steps focus on improving the credibility of empirical research, through (6) formal modelling, (7) mandatory pre-registration for confirmatory claims, (8) replication as a routine practice, (9) planning for informative studies (e.g., in terms of statistical power), and (10) making data, analysis scripts, and materials openly available. The current, quantity-based incentive structure in academia clearly stands in the way of implementing many of these practices, resulting in a research literature with sometimes questionable utility and/or integrity. As a solution, we propose a more quality-based reward scheme that explicitly weights published research by its Good Science merits. Scientists need to be increasingly rewarded for doing good work, not just lots of work